Host & Defense

SMD 8185

Co-Module Directors: Ken Miller, M.D., Pathology and Internal Medicine; Mary Jo Trout, Pharm.D., Medical Education, Geriatrics, and Pharmacology & Toxicology

Module Description: This module is an introduction to the principles of immunology, bacteriology, and virology as they apply to human disease. Peer Instruction, Team-Based Learning and WrightQ sessions all emphasize the skills necessary for diagnosing and treating infectious diseases. Throughout this module, the learner will build on foundational knowledge to solve increasingly complex case presentations.

Alignment of WrightCurriculum Educational Objectives & Milestones to the Module Learning Goals

Boonshoft SOM Educational Objectives and Milestones


What competencies / milestones will this unit address? 

Foundational Knowledge – Medical Knowledge: Master fundamental biomedical concepts, terms, processes, and system interactions


Describe normal structure and function of the human body at the molecular, cellular, tissue, organ level and all major organ systems, outlining how anatomy, biochemistry, cell biology and physiology work together


Identify the major diseases and conditions and the ways in which they operate in the body


Use scientific principles underlying diagnostic methodologies

Foundational Knowledge – Medical Knowledge:  Utilize evidence in making clinical decisions


Obtain, analyze, and synthesize information from the medical literature


Describe the fundamental components of basic, clinical and translational research

Application – Patient Care: Diagnose patient health problems


Generate a differential diagnosis by applying knowledge of the basic sciences and pathophysiology

Application – Patient Care: Propose evidence-based health maintenance and therapeutic treatments


Propose a treatment plan for common disease processes


Explain the three levels of prevention and the role of health promotion in increasing the health status of patients and populations

Human Dimension – Personal and Interpersonal Development: Reflection upon one’s personal strengths and weaknesses to make changes in one’s behavior


Integrate formative feedback from patients, peers, and faculty in order to modify behaviors

Human Dimension – Personal and Interpersonal Development: Communicate and work effectively with others


Identify roles within teams, and provide/receive effective feedback


Effectively assimilate in various teams, including interprofessional teams


Communicate clearly and empathetically in both written and verbal venues

Human Dimension – Personal and Interpersonal Development: Demonstrate leadership skills in a variety of settings


Identify characteristics of, and contribute to the development of, a high functioning team


Seek appropriate role models for leadership opportunities

Learning How to learn – Practice-Based Learning: Stimulate intellectual curiosity to question and advance knowledge through scholarship


Identify and assess the literature in an area of scholarly interest

Learning How to learn – Practice-Based Learning: Appropriately utilize evidence-based resources to address uncertainty in medicine and gaps in knowledge/skills


Recognize that gaps of knowledge and ambiguity exist in medicine

Module-Level Objectives


What are the module-level objectives for this course? 

Boonshoft SOM Objectives


Summarize the normal molecular and cellular mechanisms involved in the innate and adaptive immune responses to pathogens.



Formulate a differential diagnosis by correlating immune mechanisms with clinical findings suggestive of an immunodeficiency.

1.1, 1.3, 2.2


Describe the pathogenesis of injurious immune responses against foreign or self antigens as seen with hypersensitivity, autoimmune disorders, and transplantation, and apply appropriate pharmacotherapy.

1.1, 2.3


Correlate the structure, genetics, and pathogenesis of microbes with the clinical manifestations and laboratory diagnosis of infectious diseases.

1.1, 2.2


Justify the most appropriate pharmacotherapeutic regimen, given a clinical case presentation, based on mechanism of action, spectrum of activity, side effect profile and contraindications.

1.1, 2.3


Explain the mechanisms of active and passive immunization and compare the methods and benefits of the various types of vaccines.



Describe the epidemiology, pathogenesis, clinical manifestations, laboratory findings, treatment, and prognosis of benign and malignant disorders of the lymph nodes and white blood cells.

1.1, 1.2, 1.3, 2.2, 2.3, 3.1


Summarize the microbiology characteristics, clinical presentations, diagnosis, treatment, and prevention of the described prototypical bacteria and viruses.

1.1, 1.3, 2.3


Describe the etiologies, pathogenesis, clinical manifestations, diagnosis, and treatment of bacteremia and sepsis

1.1, 2.3


Describe how biostatistics and epidemiology are applied to clinical decisions and patient education.

1.3A, 2.3A

To review all Boonshoft SOM Educational Milestones please visit the Educational Milestones page.


Last edited on 06/21/2018.