- From the North: Take I-75 south to US 35 east (Xenia) exit. Continue on US 35 to the Main/Jefferson Sts exit (exits left). Follow signs to S. Main St and continue one-half mile to the hospital.
- From the South: Take I-75 north to US 35 east (Xenia) exit. Continue east on US 35 to the Main/Jefferson Sts exit (exits left). Follow signs to S. Main St and continue one-half mile to the hospital.
- From the West: Take I-70 east to I-75 south to the US 35 east (Xenia) exit. Continue east on US 35 to the Main/Jefferson Sts exit (exits left). Follow signs to S. Main St and continue one-half mile to the hospital.
- From the East: Take I-70 west to I-675 south. Continue south on I-675 to the US 35 west (Dayton) exit. Take US 35 west to the Main/Jefferson Sts exit. Follow signs to S. Main St and continue one-half mile to hospital.
Map of Miami Valley Hospital