Department of Pharmacology and Toxicology

Lectures and Seminars

Seminars

 2018-2019 Seminars

 For more information, contact the department at pharmtox@wright.edu.

Date

Speaker

Title

Sep 10
Location: 101 NEC Auditorium
9:30 a.m.

Host: Jeffrey Travers, M.D., Ph.D

John O’Malley, M.D., Ph.D., Assistant Professor, Harvard Medical School Brigham and Women’s Hospital, Department of Dermatology

New Concepts in Cutaneous T cell Lymphoma

Sep 19
Location: 165 Brehm
9:30 a.m.

Host: Dr. Terry Oroszi

Dr. Brian J. Lukey, Senior Toxicologist, U.S. Air Force Research Laboratory, WPAFB

Chemical Warfare during the Syrian Uprising: History and Politics

Oct 3
Location: 165 Brehm
9:30 a.m.

Host:Dr. Saber Hussain

Dr. Tyler Nelson, WPAFB

Advanced In Vitro Models for Airman Health and Performance

Oct 17
Location: 165 Brehm
9:30 a.m.

Host: Dr. Courtney Sulentic

Dr. Jeff Gearhart, WPAFB

Prediction of Toxicological Targets for Chemicals Utilizing ToxCast in vitro Data and Read-Across Approach

Oct 31
Location: 101 NEC Auditorium
9:30 a.m.

Host: Dr. Terry Oroszi

Richard (Rick) Maier, Special Agent FBI

FBI – Weapons of Mass Destruction Awareness: Countermeasures, Response and Investigations

Nov 14
Location: 165 Brehm
9:30 a.m.

Host: Dr. Yongjie Xu

Dr. Xianshu Yang, Principal Scientist, Merck Research Laboratories, Boston, MA

Directly Identifying novel lead compounds from chemical mixtures using an affinity selection mass spectrometry platform.

Past Lectures

Anita Aperia, M.D., Ph.D., presented 2017 Earl H. Morris Endowed Lecture

Anita AperiaInternationally known researcher Anita Aperia, M.D., Ph.D., was the keynote speaker at the Department of Pharmacology and Toxicology Earl H. Morris Endowed Lectureship on Thursday, Oct. 22, 2017, at Wright State University.

The event was held at 10 a.m. in the Neuroscience Engineering Collaboration Building auditorium, room 101. It was free and open to the public.

Aperia, professor of pediatrics at the Karolinska Institute in Stockholm, Sweden, spoke about the “Role of Na/K ATPase in Monogenic Neuronal Disorders and Renal Protection.”

She is known for her research on the energy efficiency of the body and its individual cells. Her pediatric cell and molecular biology lab is focused on understanding the many aspects of Na/K ATPase, which is known as the ion pump that maintains the electrochemical gradient across the plasma membrane. This enzyme has a central role in all mammalian cells and consumes more than 30 percent of all energy in the body.

Aperia’s research group has made several pioneering contributions to the understanding of specific function of neuronal Na/K ATPase. She is studying the functional consequences of disease mutations, using a variety of imaging and modeling approaches. The Na/K ATPase signal has been shown to play a major role in the protection against apoptosis, or programmed cell death, in fetal malnourishment, infections with Shiga toxin-producing E. coli and chronic kidney disease.

A native of Sweden, Aperia graduated from the Karolinska Institute Medical School and received her Ph.D. training at Yale University. She has been at the Karolinska Institute since 1976. She was the founder and project leader for the Astrid Lindgren Children’s Hospital, the largest children’s hospital in Northern Europe.

Appointed in 1987 to the Nobel Assembly for Physiology or Medicine in Stockholm, she served as a member until 2003. From 1991 through 1996, she was the first woman to chair the Nobel Assembly. She has served as a council member of the International Society of Nephrology, the International Pediatric Society of Nephrology and the European Society of Nephrology. She was the 2001 recipient of the Jean Hamburger Award and the first pediatrician to receive the prestigious international award, which recognizes outstanding research in nephrology with a clinical emphasis.

In 2011, she received the Homer W. Smith Award from the American Society of Nephrology, and in 2013, she presented the Robert W. Berliner Endowed Lecture at Yale. She also received the Torsten and Ragnar Soderberg Prize in Medicine from the Swedish Society of Medicine and another Swedish honor, His Majesty the King’s Medal.

A dedicated teacher, Aperia has been a professor for 35 years, training numerous undergraduate students and pediatric residents. She has supervised almost 50 Ph.D. students and 30 postdoctoral fellows. She also has published about 300 original papers, 40 review articles and 10 textbook chapters.


2009 Earl H. Morris Endowed Lectureship brings Nobel Prize-winner

photo of oliver smithiesNobel Prize-winner Oliver Smithies, D.Phil., Excellence professor of pathology and laboratory medicine at the University of North Carolina at Chapel Hill School of Medicine, was the keynote lecturer at the Earl Morris Symposium on July 10, 2009, at Wright State University.

On October 8, 2007, the Nobel Foundation announced that Smithies, along with Mario R. Capecchi of the University of Utah's Howard Hughes Medical Institute and Sir Martin J. Evans of the United Kingdom, would share the Nobel Prize in Physiology or Medicine. The scientists were selected "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells."

In the mid-1980s, while at the University of Wisconsin at Madison, Smithies co-discovered a technique to introduce DNA material in cells, replicating a natural process called homologous DNA recombination. He thought that genetic disorders could be treated by correcting mutations in bone marrow cells, or stem cells. This "gene targeting" led to the creation of transgenic mice, or "designer mice," that replicated human disease. Smithies' lab produced the first animal model of cystic fibrosis, a disease caused by one defective gene.

This method also enabled scientists to study specific genes by creating "knock-out mice." By targeting and removing, or knocking out, a specific gene, researchers can find out what happens when it's missing. Smithies has used the analogy of removing a steering wheel from a car; without it you soon find out why it has a steering wheel. Now this research method is commonplace in biomedical research and has been the basis for thousands of published papers.

According to the Nobel committee, "gene targeting in mice has pervaded all fields of biomedicine. Its impact on the understanding of gene function and its benefits to mankind will continue to increase over many years to come."


About the Morris Lectureship

An endowed lectureship was established by the family of Dr. Mariana Morris, former chair and professor of pharmacology and toxicology, in honor of her grandfather, Dr. Earl H. Morris. The first invited speaker was Suzanne Oparil, M.D., professor of medicine and director of the Vascular Biology and Hypertension Program at the University of Alabama at Birmingham, who came to Wright State in May 2000. In May 2002, the Earl H. Morris Stress Symposium was held with guest speaker Paul Plotsky, Ph.D., of Emory University, who addressed "Early Adverse Experience as a Developmental Risk Factor."

Rodolfo Llinas, M.D., Ph.D., Thomas and Suzanne Murphy professor of neuroscience and chair of the Department of Physiology and Neuroscience at New York University School of Medicine, presented the Earl H. Morris Lecture on Oct. 17, 2004. A world renowned neuroscientist who pioneered important concepts of neural circuitry and communication within the brain, Dr. Llinas presented "The Neurobiology of Consciousness."

Salvador Moncada, M.D., Ph.D., D.Sc., director of The Wolfson Institute for Biomedical Research at the University College London, presented the Earl H. Morris Lecture on June 22, 2005. Professor Salvador Moncada has revolutionized understanding cardiovascular function and pathology through his research on the role of nitric oxide as a signaling molecule. He presented, "Nitric Oxide, Mitochondria and Cell Signaling."


About Earl Morris, M.D.

photo of earl morrisphoto of earl morrisDr. Earl H. Morris was born in Bellbrook, Ohio, in 1872 and received his M.D. From the University of Cincinnati Medical School in 1903. The Montgomery County and Ohio State Medical Societies honored him in 1954 for 50 years of medical practice. The annual lecture series was endowed by his son and daughter-in-law, Herbert C. and Marion Morris.

"An avid learner throughout his lifetime, he was keenly interested in medical research and advances in clinical practice," explains his granddaughter, Mariana Morris, Ph.D., former chair of the Department of Pharmacology and Toxicology. "This lectureship is a tribute to his lifelong dedication to the science of medicine."

Last edited on 10/11/2018.