Origins
SMD 8170
Module Director: John Paietta, Ph.D., Biochemistry & Molecular Biology; Michael Matott, PhD
Module Description: The first part of the Origins module covers the fundamentals of molecular biochemistry with application to normal and disease states. The module’s focus on biochemistry, molecular biology, and genetics will provide a solid basis for understanding the molecular and genetic basis of disease. Peer instruction and team-based learning will highlight clinical correlations with emphasis on the molecular mechanisms involved, as well as, therapeutic interventions.
The second part of the Origins module is intended to provide students with the cellular physiology and pharmacology basics needed to understand how organs function, in particular how water and ion concentrations are maintained to support epithelial transport, excitability, and neurotransmission, and the wide repertoire of receptor-mediated signaling that regulates or carries out these functions. The fundamental principles will be revisited as learners more specifically investigate the anatomy, physiology and pharmacology of the autonomic nervous system and of muscle. The course goes beyond normal function to examine pathophysiological mechanisms involved in cancer and tissue injury and repair.
Alignment of WrightCurriculum Educational Objectives to the Module Learning Goals
Boonshoft SOM Educational Objectives
|
Code |
What competencies will this unit address? |
|---|---|
|
Foundational Knowledge – Medical Knowledge |
|
|
1.1 |
Master fundamental biomedical concepts, terms, processes, and system interactions |
|
1.3 |
Utilize evidence in making clinical decisions |
|
Human Dimension – Personal and Interpersonal Professional Development Goals |
|
|
4.1 |
Integrate formative feedback from patients, peers, and faculty in order to modify behaviors |
|
4.5 |
Communicate and work effectively with others |
|
4.6 |
Demonstrate leadership skills in a variety of settings |
|
Caring/Valuing – Professionalism Goals |
|
|
5.3 |
Value and behave in a manner consistent with the highest ethical standards of the profession |
|
Learning How to learn – Practice-Based Learning |
|
|
6.2 |
Stimulate intellectual curiosity to question and advance knowledge through scholarship |
|
6.3 |
Appropriately utilize evidence-based resources to address uncertainty in medicine and gaps in knowledge/skills |
Module-Level Objectives
|
Code |
What are the module-level objectives for this course? |
Boonshoft SOM Objectives |
|---|---|---|
|
LO1 |
Describe the production, utilization, and storage of energy under aerobic and anaerobic conditions both qualitatively and quantitatively |
1.1, 1.3 |
|
LO2 |
Describe how genetic information is expressed and transmitted, including the structure of DNA and RNA, replication, repair, transcription, translation, and epigenetic mechanisms |
1.1, 1.3 |
|
LO3 |
Assess how the structure and function of proteins relates to homeostasis, signaling events (mechanisms, pathways), disease, and pharmacotherapy |
1.1, 1.3 |
|
LO4 |
Analyze how the synthesis and metabolism of carbohydrates, lipids, nucleotides, and amino acids supports homeostasis and how dysregulation relates to disease |
1.1, 1.3 |
|
LO5 |
Interpret how environment affects the structure and function of nucleic acids, proteins, carbohydrates, and lipids in homeostasis |
1.1, 1.3 |
|
LO6 |
Examine and assess how genomic variation affects the choice, benefits, and adverse effects of pharmacotherapy |
1.1, 1.3 |
|
LO7 |
Summarize the principles of receptor pharmacology |
1.1 |
|
LO8 |
Apply principles of pharmacokinetics in determining appropriate drug therapy |
1.1 |
|
LO9 |
Relate the properties of cell structure, barriers between tissues, and connective tissue, to normal functions of cells and organ systems, and to abnormal states such as cell injury and neoplasms |
1.1 |
|
LO10 |
Indicate the mechanisms by which cells respond to injury and stress and how they correlate with clinical abnormalities |
1.1 |
|
LO11 |
Compare and contrast the basic characteristics of benign and malignant neoplasms |
1.1 |
|
LO12 |
Identify the molecular and genetic mechanisms disrupted in cancer and how antineoplastic pharmacologic agents target these mechanisms |
1.1 |
|
LO13 |
Explain how cells transport solutes and maintain water balance throughout the body’s compartments |
1.1 |
|
LO14 |
Interpret how the properties of cell membranes contribute to cellular excitability and nerve conduction. Apply these principles to diseases |
1.1 |
|
LO15 |
Identify the mechanisms that underpin communication between excitable cells in the peripheral and central nervous systems |
1.1 |
|
LO16 |
Compare and contrast the key properties of the sympathetic and parasympathetic nervous system and describe the effects of pharmacologic agents |
1.1 |
|
LO17 |
Compare and contrast the structural and functional components of skeletal, smooth, and cardiac muscle |
1.1 |
|
LO18 |
Demonstrate professional behavior during interactions with patients and their families, peers, and instructors in a variety of settings |
4.5, 5.3 |
|
LO19 |
Use critical judgment and problem-solving skills to integrate the principles of evidence based medicine with biomedical and clinical sciences |
1.3, 6.2 |
|
LO20 |
Use effective communication and leadership skills when working with others |
4.5, 4.6 |
|
LO21 |
Perform self-assessment to identify gaps in knowledge and address deficiencies |
4.1, 6.3 |
