Origins 1

SMD 8170

Module Director: John Paietta, Ph.D., Biochemistry & Molecular Biology

Module Description: Origins 1 covers the fundamentals of molecular biochemistry with application to normal and disease states.  The module’s focus on biochemistry, molecular biology, and genetics will provide a solid basis for understanding the molecular and genetic basis of disease.  Peer instruction and team based learning will highlight clinical correlations with emphasis on the molecular mechanisms involved, as well as, therapeutic interventions.

Alignment of WrightCurriculum Educational Objectives & Milestones to the Module Learning Goals

Boonshoft SOM Educational Objectives and Milestones


What competencies / milestones will this unit address? 

Foundational Knowledge – Medical Knowledge: Master fundamental biomedical concepts, terms, processes, and system interactions


Describe normal structure and function of the human body at the molecular, cellular, tissue, organ level and all major organ systems, outlining how anatomy, biochemistry, cell biology and physiology work together


Identify the major diseases and conditions and the ways in which they operate in the body


Use scientific principles underlying diagnostic methodologies

Foundational Knowledge – Medical Knowledge: Utilize evidence in making clinical decisions


Obtain, analyze, and synthesize information from the medical literature


Describe the fundamental components of basic, clinical and translational research

Human Dimension – Personal and Interpersonal Professional Development Goals: Reflection upon one’s personal strengths and weaknesses to make changes in one’s behavior


Integrate formative feedback from patients, peers, and faculty in order to modify behaviors

Human Dimension – Personal and Interpersonal Professional Development Goals: Communicate and work effectively with others


 Identify roles within teams, and provide/receive effective feedback


Effectively assimilate in various teams, including interprofessional teams


Communicate clearly and empathetically in both written and verbal venues

Human Dimension – Personal and Interpersonal Professional Development Goals: Demonstrate leadership skills in a variety of settings


Identify characteristics of and contribute to the development of a high functioning team


Seek appropriate role models for leadership opportunities

Caring/Valuing – Professionalism Goals: Value and behave in a manner consistent with the highest ethical standards of the profession


Identify the basic principles of medical ethics

Learning How to learn – Practice-Based Learning: Stimulate intellectual curiosity to question and advance knowledge through scholarship


Identify and assess the literature in an area of scholarly interest

Learning How to learn – Practice-Based Learning: Appropriately utilize evidence-based resources to address uncertainty in medicine and gaps in knowledge/skills


Recognize that gaps of knowledge and ambiguity exist in medicine

Module-Level Objectives


What are the module-level objectives for this course? 

Boonshoft SOM Objectives


Describe the production, utilization, and storage of energy under aerobic and anaerobic conditions both qualitatively and quantitatively.

1.1a,b,c; 1.3a


Describe how genetic information is expressed and transmitted, including the structure of DNA and RNA, replication, repair, transcription, translation, and epigenetic mechanisms.

1.1a,b,c; 1.3a


Identify, compare, and analyze how mutations and epigenetic factors drive the development of neoplasia, recognizing the impact of environmental, ethnic, and age-related variance among populations.

1.1a,b,c; 1.3a


Assess how the structure and function of proteins relates to homeostasis, signaling events (mechanisms, pathways), disease, and pharmacotherapy.

1.1a,b,c; 1.3a


Analyze how the synthesis and metabolism of carbohydrates, lipids, nucleotides, and amino acids supports homeostasis and how dysregulation relates to disease.

1.1a,b,c; 1.3a


Interpret how environment affects the structure and function of nucleic acids, proteins, carbohydrates, and lipids in homeostasis.

1.1a,b,c; 1.3a


Examine and assess how genomic variation affects the choice, benefits, and adverse effects of pharmacotherapy.

1.1a,b,c; 1.3a


Demonstrate professional behavior during interactions with patients and their families, peers, and instructors in a variety of settings.

4.5a,b,c; 5.3a


Use critical judgment and problem-solving skills to integrate the principles of evidence based medicine with biomedical and clinical sciences.

1.3a,b; 6.2a


Use effective communication and leadership skills when working with others.

4.5a,b,c; 4.6a,c


Perform self-assessment to identify gaps in knowledge and address deficiencies.

4.1a; 6.3a

To review all Boonshoft SOM Educational Milestones please visit the Educational Milestones page.


Last edited on 07/25/2017.